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	Provedor de dados BJMBR (1) Autor Mantovani,M. (1) Matteussi,A.S. (1) Rodrigues,A.L.S. (1) Palavra-chave Depression (1) Forced swimming test (1) Lead acetate (1) Open-field (1) Tipo do documento Info:eu-repo/semantics/other (1) Ano 1999 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Antidepressant-like effect of lead in adult mice BJMBR Mantovani,M.; Matteussi,A.S.; Rodrigues,A.L.S.. It has been reported that lead can cause behavioral impairment by inhibiting the N-methyl-D-aspartate (NMDA) receptor complex. MK-801, a noncompetitive NMDA receptor antagonist, exhibits an antidepressant-like action in the forced swimming test. The purpose of the present study was to determine whether subacute lead exposure in adult male Swiss mice weighing 30-35 g causes an antidepressant-like action in a forced swimming test. Mice were injected intraperitoneally (ip) with 10 mg/kg lead acetate or saline daily for 7 consecutive days. Twenty-four hours after the last treatment, the saline and lead-treated mice received an injection of MK-801 (0.01 mg/kg, ip) or saline and were tested in forced swimming and in open-field tests. Immobility time was... Tipo: Info:eu-repo/semantics/other Palavras-chave: Lead acetate; Forced swimming test; Depression; Open-field. Ano: 1999 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200017 Registros recuperados: 1 Primeira ... 1 ... Última

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